BEOnChip organ on a chip technology consists of microfluidic cell culture chips that aim to reproduce different physiological responses of organs in-vitro in the lab. They simulate mechanical and chemical conditions to make the environment as biomimetic as possible. Biomimetics is the imitation of systems in nature for the purpose of solving complex human problems.
BE-FLOW
In vitro simulation of physiological environments involving flow and shear stress Long-term 2D experiments in three independent channels under flow conditions.
APPLICATIONS
- Vascular research
- Mechanical shear stress
- Interstitial flow
- Portal - Central vein sinusoids
- Defined liquid Exchange
- Rolling and adhesion
BE- GRADIENT
Interstitial flow is applied through the hydrogel to provide cells with nutrients, O2, and CO2 to maintain optimal conditions.
APPLICATIONS
- Cell migration
- Spheroid substitution
- Necrotic core
- Nutrient, DO2 and drug gradient
- Stem cell differentiation 3D
- Angeogenesis
- Oxidative stress
- Inmune system
TRANSFLOW
A combination of a 2D-3D organized co-culture. It aims to replicate different tissue structures.
Advanced in vitro immune system assays could be possible.
APPLICATIONS
- Cancer-metastasis in vitro model
- SKIN on chip (Animal free testing)
- GUT on chip
- KIDNEY on chip
- BONE on chip
- Wound healing
- Diabetic model
- Brain Blood Barrier
- Toxicity testing
- Absorption in vitro model
- Air-liquid interface